How is it Inherited?
To obtain the sickle cell disease, an allele for that trait must already be present in both parents of the child. If there is a man and a woman who are both negative for the sickle cell gene, then their child will not be a carrier or obtain the disease. If the man or woman in the relationship is a carrier for this trait, and his/her partner is clean, then there is a 50% chance that their child would be a carrier and not a sickler. If the man or woman has sickle cell and his/her partner is healthy, then they can only have children who are carriers of the disease. If both the man and woman carry the disease, then there is a 25% chance that they will have a healthy child, a 50% chance that they will have a carrier, and a 25% chance that they will have a sickler child. If a man or woman has the sickle cell disease, and his/her partner is a carrier, 50% of their children will either be sickle cell carriers or have the sickle cell disease. Finally, if both man and woman in a relationship have the sickle cell disease, then all their offspring will be guaranteed to be sicklers. Even if one does not have the sickle cell disease, it can be spread to offspring in a relationship with a sickler.